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  • Writer's pictureElena Cora

Clinical Applications of Antioxidant Medicine in Male Infertility: Enhancing Sperm Count and Motility

Certain medications are known to decrease sperm count, motility, or morphology - such as anabolic steroids over extended use periods; certain antidepressants (citalopram, fluoxetine, paroxetine and venlafaxine); as well as certain narcotics.


Thiopurines (azathioprine, 6-MP) may cause reversible decreases in semen parameters and an increased risk of miscarriage or birth defects in offspring, but an herbal supplement called Ashwagandha has been found to improve their sperm health.




Antioxidants:


Antioxidants are natural substances that protect the body against oxidative damage, with metabolic processes producing reactive oxygen species (ROS). Although ROS can have detrimental effects on individual cells, tissues and organs, the body has antioxidants in place that mop up these molecules before they have any lasting consequences. Oxidative stress has also been shown to cause DNA damage that reduces fertility levels resulting in lower sperm function and fertility levels.


Numerous nutrients act as antioxidants, such as vitamins A and E, zinc, selenium, Coenzyme Q10 and polyunsaturated fats. Studies have shown that supplementing with antioxidants may improve sperm function and fertility among men with low sperm counts or high ROS levels.


Multiple double-blind clinical trials have demonstrated that using ubiquinone can significantly improve sperm concentration and motility. Ubiquinone, a coenzyme produced in the liver, can be found in foods like meat, fish, eggs, broccoli, peanuts and olive oil.


Vitamin C also has been proven to boost immunity while decreasing oxidative damage to sperm; taking 500-1,000 mg daily of vitamin C can improve count and motility as well. Supplements which may also help include omega-3 and omega-6 fatty acids zinc and pakistan herbal products.


Maca root:


Maca root (Lepidium meyenii) has been used by natives of Central South America's Andes region for millennia as both food and medicine. Maca is believed to help increase energy and fertility as well as increase libido and semen quality; however, its effects can often vary between products, sample sizes, and the impact of other diet factors on hormone levels.


Studies have demonstrated that maca can increase sperm concentration and motility in men. Yet more research is necessary to ascertain its efficacy in treating male infertility; additionally, results of these studies may not apply universally or be reflective of real world findings due to being conducted without double blind studies being performed on participants.


Maca is generally considered safe and well-tolerated with few side effects, making it suitable for supplement use in tablets, capsules or powder form. Anyone considering trying maca should consult with their health care provider first in order to be sure it is suitable.


Note that maca can increase estrogen levels so it should not be taken by pregnant or breastfeeding women and those suffering from conditions that are sensitive to hormones such as endometriosis or uterine fibroids.

 

Coenzyme Q10:


Coenzyme Q10, an antioxidant present in all living organisms and food sources, may aid in increasing both sperm count and motility. Dietary supplements do not fall under FDA regulations like medications do, so their safety has not been extensively tested; however one study conducted by Fertility & Sterility demonstrated that those taking 200 mg of coenzyme Q10 daily saw increased levels of it in their seminal fluid as well as an improvement in motility.


Recent studies comparing two doses of CoQ10 --200 and 400 mg/day--were also conducted. Participants diagnosed with idiopathic oligoasthenoteratospermia (OAT) were randomly assigned either CoQ10 or placebo for 26 weeks followed by 30 weeks without treatment;


blood and seminal plasma CoQ10 levels were evaluated before and after trial; concentration, forward motility, morphology were all also evaluated; this showed significant improvements compared with control group in all three sperm parameters while positive correlation between blood and seminal plasma CoQ10.


Ashwagandha can also be used as an antioxidant to improve sperm count and motility; research conducted on this herbal remedy showed it could significantly increase testosterone levels and sperm count; however, more top hakeem in lahore research should be conducted before making definitive statements about any such benefits.


D-aspartic acid:


D-aspartic acid (also referred to as L-aspartic acid) is an amino acid found naturally in glandular tissues and sperm cells. It plays an integral part in regulating testosterone release and synthesis; one study found supplementing men for 90 days with D-aspartic acid doubled sperm concentration by over 50% while motility increased over 50% as well.


Another supplement that may help increase sperm count and motility is selenium; selenium acts as an antioxidant that protects sperm from oxidative damage when combined with vitamins C and E; numerous studies have demonstrated how using selenium can improve count, motility and morphology significantly.

Other supplements known to enhance sperm count and motility include maca root, ashwagandha (Winter melons), vitamin D and coenzyme Q10.


One study demonstrated how taking 2.5 grams of dried maca root powder daily for four months increased self-reported libido among men suffering mild erectile dysfunction; another demonstrated how taking 1.75 grams per day of maca root increased both sperm count and motility among healthy male participants.


Studies have demonstrated that supplementing with 1000 mg of Vitamin C daily for two months is hakim online to significantly increase sperm count and motility, as well as reduce deformed cells in infertile men, as well as folic acid and zinc being beneficial in improving their sperm health. Other research studies suggest other supplements like omega-3 fatty acids (EPA and DHA), L-carnitine, Folic acid and Zinc could also aid in improving their health.

 

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