Men who experience mild decreases in sperm count or motility may find relief through oral medication such as Clomiphene Citrate. This drug stimulates the pituitary gland into producing more LH/FSH.
Some medications prescribed to HIV patients such as ACE-inhibitors (captopril and enalapril) and mTOR inhibitors (sirolimus and everolimus) have been shown to decrease semen parameters; this change was found to be reversible.
Acetaminophen:
Acetaminophen, the active ingredient found in Tylenol, can be an effective pain reliever but can be detrimental to fertility. According to animal studies, high doses of acetaminophen were shown to significantly reduce semen quality in mice due to its interference with DNA repair mechanisms and replication causing DNA breaks and subsequent loss of motility and morphology loss resulting in reduced semen quality and motility loss.
Acetaminophen is a commonly prescribed over-the-counter medication, but its effects can have detrimental impacts on fertility. Studies have revealed that men taking this medication are more likely to experience fertility problems; additionally, taking this drug may lower libido and frequency of ejaculation; however there are solutions that may improve sperm health such as antidepressants and supplements containing antioxidants; antibiotics are another class of medications which have the power to influence both quantity and quality; these antibiotics are typically prescribed by healthcare practitioners treating testicles or epididymis infections in these two areas of the man power medicine.
Antidepressants:
These include antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), such as paroxetine. A rat study discovered that paroxetine reduced sperm count while increasing DNA fragmentation.
However, in 2021 a study with 68 men using duloxetine as an SNRI revealed no reduction in either sperm count or ejaculation rate while improving its morphology. Researchers further observed that lower doses had no impact on sperm counts or motility.
Ant epilepsy drugs (carbamazepine, oxcarbazepine and valproate) and antiretroviral such as zidovudine and nevirapine) may also influence sperm count and motility; they include carbamazepine, oxcarbazepine, and valproate as well as zidovudine and nevirapine are considered effective antiretroviral against HIV infection; some gout medications including colchicine have been linked with testicular dysfunction as well as decreases in parameters; speak to your physician about switching or lowering dose; alternatively lifestyle changes could help enhance fertility as well.
ACE-inhibitors:
ACE inhibitors are medications designed to limit the activity of an enzyme called angiotensin-converting enzyme (ACE). Commonly used to treat high blood pressure, these ACE inhibitors have also been demonstrated as being capable of increasing sperm count and motility in recent studies.
These medications include selegiline, isocarboxazid, phenelzine and tranylcypromine - commonly prescribed but with high rates of sexual dysfunction and only small human studies conducted to date [Beeder LA. Int J Urol 2019]
SSRIs are among the most widely prescribed antidepressants, and have been linked to fertility issues among male users. This could be caused by oxidative stress, hormonal shifts or impaired ductal transport of sperm; studies have demonstrated this with fluoxetine, paroxetine, sertraline and citalopram all having some degree of spermicidal activity; long term use of narcotics is also thought to adversely impact sperm quality as they negatively influence testosterone levels.
Thiopurines:
Thiopurines (azathioprine and its active metabolite 6-mercaptopurine) represent an innovation in drug discovery that transformed pharmaceutical development; these innovative treatments for leukemia, organ transplantation, inflammatory bowel disease, systemic lupus erythematosus and other chronic autoimmune conditions were first developed during the 1950s - they may even have contributed to eliminating childhood leukemia by eliminating resistance genes from B lymphocytes.
Thiopurine use has been linked with decreased sperm count, motility and ejaculate fluid volume; however these effects are reversible upon discontinuing medication use. Furthermore, 5-ASA compounds without the sulfapyridine component - such as mesalamine (5-ASA) - have proven significantly safer for fertility than its parent drug, azathioprine.
Calcineurin inhibitors (CNIs), such as Cyclosporine A (CSA) and tacrolimus, may have negative impacts on sperm parameters in human and animal studies; this may be the result of chronicity, severity and patient population sex power medicine.
Methotrexate:
Methotrexate, a folic acid antagonist medication, is often prescribed to women during reproductive years for treating their inflammatory bowel diseases; however, its use should be restricted as pregnancy-category X medication as it could result in birth defects for their offspring.
Researchers examined the effects of low-dose methotrexate exposure on sperm quality by analyzing semen samples from both patients’ exposed and healthy controls. They evaluated fragmentation, concentration, progressive motility and morphology measurements along with measuring oxidative stress adducts and DNA stainability within semen samples.
Results revealed that patients receiving low dose methotrexate had comparable sperm quality to healthy volunteers, without increased DNA fragmentation. Additionally, paternal preconception methotrexate exposure did not increase risks of congenital anomalies, PTB or SGA in offspring; nor did it increase need for intracytoplasmic sperm injection in couples suffering male factor infertility.
Clomiphene citrate:
Clomiphene citrate (Clomid) is an estrogen-receptor modulator (SERM), used to increase sperm count and motility in men. Commonly referred to by its brand name Clomid, this medication is often prescribed to induce ovulation in female users and raise testosterone levels in male users who can then improve sperm quality through increased testosterone production resulting in improved motility - it has even shown promising results with up to 70% of low sperm count cases!
CLOMID can also increase LH and FSH levels to promote testicular sperm production and motility. Studies have demonstrated a positive impact on count and motility for men with idiopathic best sex medicine in pakistan.
Studies have demonstrated that taking Clomiphene citrate combined with vitamin E may increase pregnancy rates for men suffering from idiopathic oligoasthenozoospermia; however, further studies are required to verify this finding. Furthermore, this medication could decrease cervical mucus production which makes it harder for sperm to enter the uterus.
Commentaires